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Do not take 2 doses of PIFELTRO at the same time. If it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. If you miss a dose of PIFELTRO, take it as soon as you remember.Take PIFELTRO on a regular dosing schedule as instructed by your health care provider.Stay under a healthcare provider’s care when taking PIFELTRO. Do not change your dose or stop taking PIFELTRO without talking to your health care provider.You may not have enough doravirine in your blood if you take rifabutin during treatment with PIFELTRO. If you take the medicine rifabutin during treatment with PIFELTRO, take PIFELTRO 2 times each day, about 12 hours apart, as prescribed by your health care provider.Tell your health care provider if you have taken rifabutin in the past 4 weeks.Take PIFELTRO 1 time each day, at about the same time every day. Take PIFELTRO every day exactly as your health care provider tells you to take it.Your health care provider can tell you if it is safe to take PIFELTRO with those other medicines. Do not start taking a new medicine without telling your health care provider.

Keep a list of your medicines to show your health care provider and pharmacist.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Women with HIV should not breastfeed because their babies could be infected with HIV through their breast milk. It is not known if PIFELTRO can harm your unborn baby.

Before starting PIFELTRO, tell your health care provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

For more information, ask your health care provider or pharmacist.

These are not all the possible side effects of PIFELTRO.

The most common side effects of PIFELTRO include: nausea, dizziness, headache, tiredness, diarrhea, stomach (abdominal) pain, and abnormal dreams.

Tell your health care provider right away if you start having new symptoms after starting your HIV-1 medicine. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time.

Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines.

If you have taken any of the medicines in the past 4 weeks, talk to your health care provider or pharmacist before starting PIFELTRO.

Ask your health care provider or pharmacist if you are not sure if your medicine is one that is listed above.

Do not take PIFELTRO if you are currently taking any of the following medicines: carbamazepine, oxcarbazepine, phenobarbital, phenytoin, enzalutamide, rifampin, rifapentine, mitotane, St.